Within the target region, 887 SNPs were listed in HapMap (Rel 23a/phase II Mar08 dbSNP b126) of which 508 had MAF≥0.01. To these, we added the genotype data for 21 SNPs from our exonic de novo polymorphism detection. From these, we identified 209 non-redundant (r2=1 in CEU) markers. Of the 209 markers, we were able to obtain genotypes for 176 in fatSNP phase 1. Overall, the genotyped markers provide coverage of 91% of target alleles with MAF ≥0.01 at r2=1 and 96% coverage at r2≥0.9. For alleles with MAF ≥0.05, the respective figures are 93% and 97%. Association results are summarized in Figure 1 and in supplemental table 3. A total of 12 markers (in addition to rs1344706) met our criteria for follow up (table 1. note rs12613195 was inc1uded as it attained the threshold in the full GWAS sample. Also note rs6726421 was taken forward as a perfect proxy for the non-synonymous SNPs described in table 1). Notably, in this sub-sample of our GWAS (fatSNP1), 3 markers yielded slightly stronger evidence for association than our original GWAS marker (table
