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Chunk #29 — Results — fatSNP study — fatSNP1

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Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder.
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Also note rs6726421 was taken forward as a perfect proxy for the non-synonymous SNPs described in table 1). Notably, in this sub-sample of our GWAS (fatSNP1), 3 markers yielded slightly stronger evidence for association than our original GWAS marker (table 1). Of these, two (rs1583048 and rs3931790, r2=1) were the putative eQTLs with strongest evidence for association to expression in Genvar (rs7593816, an equally strong eQTL that is perfectly correlated with those SNPs failed genotyping), with the schizophrenia-associated allele being associated with higher gene expression (supplemental table 2). The other SNP, rs17584522, is intronic.