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Chunk #7 — Material and Methods — Subjects and assessment

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Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism.
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Personality traits were assessed using the NEO-PI-R questionnaire 27 at all waves for parents and starting at wave 6 (older than age 18) for offspring. Analyses compared the percentage of alcohol dependence symptoms with the personality trait Impulsiveness, a Neuroticism facet of the NEO-PI-R 27 and two GABRA2 SNPs.