One class of methods seeks to determine whether eQTL and GWAS signals are colocalized or are distinct although linked by LD. This class includes COLOC18, Sherlock17, and RTC1, and more recently eCAVIAR19, and ENLOC20. Thorough comparison between these methods can be found in refs. 18,19. HEIDI, the post filtering step in SMR that estimates heterogeneity of GWAS and eQTL signals, can be included in this class. We focus here on COLOC, whose quantification of the probability of five configurations complements well with S-PrediXcan results.
