COLOC provides the probability of five hypotheses: H0 corresponds to no eQTL and no GWAS association, H1 and H2 correspond to association with eQTL but no GWAS association or vice-versa, H3 corresponds to eQTL and GWAS association but independent signals, and finally H4 corresponds to shared eQTL and GWAS association. P0, P1, P2, P3, and P4 are the corresponding probabilities for each configuration. The sum of the five probabilities is 1. The authors18 recommend to interpret H0, H1, and H2 as limited power; for convenience we will aggregate these three hypotheses into one event with probability 1-P3-P4.
