recorded from parietal-occipital brain regions (Jones et al. 2004, 2006a). These findings implicate CHRM2 in the generation and modulation of these oscillations underlying the P3 response to target stimuli. They are supported by the observations that the generation of θ and δ oscillations depend on the level of activation of the M2 autoreceptors by acetylcholine (Fellous and Sejnowski 2000; Tiesinga et al. 2001). These receptors inhibit further acetylcholine release by the presynaptic cells, thus leading to inhibition of irrelevant networks. Other studies have suggested that acetylcholine plays a role in stimulus significance (Perry et al. 1999), selective attention (Mitrofanis and Guillery 1993), P3 generation, and modified memory performance (Callaway 1983; Dierks et al. 1994; Frodl-Bauch et al. 1999; Hammond et al. 1987; Potter et al. 2000). Thus, the genetic underpinnings of these oscillations likely stem from regulatory genes that control the neurochemical processes of the brain, thereby influencing neural function.
