Results from the item-level logistic regression models in the EUR subset of the NESARC-III sample are shown in Figure 3. As the sole PGS predictor (Figure 3a and Supplemental Table 10), the DSM-NicDep PGS was significantly associated with all 11 DSM criteria (p FDR < 0.05) and 2 of the 4 FTND items (how soon after waking is the first cigarette smoked, and whether one smokes more frequently during the early hours of the day). The DSM-NicDep PGS was also associated with the total number of endorsed DSM-5 TUD criteria (β = 0.116, SE = 0.025, p FDR = 7.1e−5, variance explained = 0.17%) and total number of endorsed FTND items (β = 0.033, SE = 0.010, p FDR = 0.003, variance explained = 0.08%). When the FTND PGS was the sole predictor, it was associated with all 4 FTND items and 9 of 11 DSM criteria (Figure 3b), as well as the total number of endorsed DSM-5 TUD criteria (β = 0.118, SE = 0.025, p FDR = 7.2e−6, variance explained = 0.2%) and total number of endorsed FTND
