items and 9 of 11 DSM criteria (Figure 3b), as well as the total number of endorsed DSM-5 TUD criteria (β = 0.118, SE = 0.025, p FDR = 7.2e−6, variance explained = 0.2%) and total number of endorsed FTND items (β = 0.052, SE = 0.010, p FDR = 1.3e−6, variance explained = 0.2%; Supplemental Table 11). When all four PGS were included as predictors (Figure 3c and Supplemental Table 12), the DSM-NicDep PGS was no longer associated with any individual DSM or FTND items nor the total criterion counts. Overall, the ICD-TUD PGS was the strongest predictor of endorsement of individual DSM and FTND items, but the variance explained was still quite small (maximum variance explained = 0.716%).
