In a model that included DSM-NicDep, FTND, and CPD PGSs as joint predictors, the DSM-NicDep PGS was significantly associated with TUD in the EUR subset of the BioVU biobank (odds ratio [OR] = 1.013, 95% CI = [1.01, 1.016], p = 5.7e−18), as was the PGS for CPD (OR = 1.017, 95% CI = [1.014, 1.02], p = 1.3e−31). The PGS for FTND was also significantly associated, but with an even smaller effect size (OR = 1.006, 95% CI = [1.003, 1.009], p = 1.6e−5). Altogether, the PGS explained 0.58% of the variance in ICD-TUD, while the DSM-NicDep PGS alone explained 0.12% of the variance in ICD-TUD after accounting for the variance explained by the other PGS (Supplemental Table 13).
