Of the affective symptoms rated by trained SSAGA interviewers, no significant differences between bipolar groups were detected over time (MANOVA F-value: 0.76; df 3; p: 0.842). GAF (social functioning) scores significantly improved in Groups 1, 3, and 4 over time; while for Group 2 subjects, a significant decrease in their level of social functioning was observed (MANOVA F-value: 5.17; df 3; p < 0.02, see Table 6).