In EAs PDLIM5 rs10031423 showed a significant association with AD symptom counts. In EAs, we identified 59 variants with significant effect on this association. Except for ADH1B rs1229984 (i.e., a genome-wide significant variant for AD symptom counts in EAs), they are all located in the PDLIM5 gene region, and 36 of them have an r2<0.2 with rs10031423 both in the Yale–Penn and SAGE datasets (Supplementary Table 7). Among these non LD variants, there are ADH1B rs1229984 and PDLIM5 rs2452594. This latter may have functional impact on the PDLIM5 function (RegulomeDB score = 2b, i.e., TF binding + any motif + DNase Footprint + DNase peak) and this variant reduces the association of rs10031423 with AD symptom count (meta-analyzed p-value from 7.3510−6 to 5.75*10−4). In AAs, we identified 88 variants with significant z-scores (Supplementary Table 8). Except for KCND2 rs12333476, they are all located on chromosome 4, as rs10031423. Among these variants, rs6853490 (z = −20.085) showed that a high African ΔF, may play a role in PDLIM5 regulation (RegulomeDB score = 2b, i.e., TF binding + any motif + DNase
