are all located on chromosome 4, as rs10031423. Among these variants, rs6853490 (z = −20.085) showed that a high African ΔF, may play a role in PDLIM5 regulation (RegulomeDB score = 2b, i.e., TF binding + any motif + DNase Footprint + DNase peak), and increase the association of rs10031423 with AD symptom count in AAs (meta-analyzed p-value from 0.276 to 0.097). Regarding ADH1B rs1693457 (significant in AAs), through our analysis of AAs, we identified 27 variants with significant z-scores. They are all located in the surrounding regions of rs1693457 (Supplementary Table 9). Among these, 18 variants showed r2 <0.2 with rs10031423 both in the Yale–Penn and SAGE datasets. In accordance with RegulomeDB, none of these seem to have functional impact on PDLIM5 gene function. However, rs12639887 (z = 16.997) showed the highest African ΔF among these (Africa ΔF = 0.39). Both the VARIANT tool and rSNPbase identified it as regulatory SNP, and rs12639887 reduces the association significance of rs1693457 with AD symptom counts (meta-analyzed p-value from 3.40*10−9 to 1.10*10−5). In EAs, we identified 106 variants with significant z-scores. All of these are located in the regions surrounding rs10031423 (Supplementary Table 10). According to RegulomeDB, none of them showed notable
