WGS and receiving results would yield individual, family, community and societal benefits. Among those benefits was a sense of reassurance that might come from receiving “good results.” Currently such results are not being considered for return by most, but participants’ expectations may require researchers and clinicians to consider returning negative results and results for protective alleles [Knoppers et al., 2006], and to develop more effective ways of communicating relative risk information including variants of unknown significance [Lemke et al., 2012]. Moreover, these findings highlight that the risks and benefits of receiving results must be considered using a broader framework, at least in conjunction with discussion about disclosing only clinically actionable results.
