For 33 regions, the 95% credible set contained 5 or fewer SNPs (Supplementary Table 11c) and for 9, only a single SNP. We highlight rs4766428 (PP>0.99) which is the only credible SNP in a locus that contains 25 genes and is located within ATP2A2. Mutations in ATP2A2 cause Darier Disease21, which co-segregates with bipolar disorder in several multiplex pedigrees and is associated with bipolar disorder and schizophrenia at a population level22. ATP2A2 encodes a sarcoplasmic/endoplasmic reticulum calcium pump, suggesting that its role in schizophrenia pathogenesis may be through regulating neuronal cytoplasmic calcium levels. The likely relevance of calcium metabolism is also suggested by enrichment for associations in and around voltage-gated calcium channels (Supplementary Tables 3 and 7).
