We denote as our broad fine-map set 628 genes (435 protein coding) that contained at least one credible SNP (Figure 1). To identify the most credible causal genes, we prioritised those mapping to the 287 loci that were genome-wide significant in our Extended GWAS that also contained a) at least one nonsynonymous (NS) or untranslated region (UTR) variant with a PP> 0.1 b) the entire credible set (Supplementary Tables 13, 14). These protein-coding genes had a greater than 3-fold enrichment for loss of function intolerance compared with other protein-coding genes within the loci that were not tagged by credible SNPs (Supplementary Table 15; Supplementary Note), supporting our strategy to delimit credible causal genes.
