Among the 70 FINEMAP prioritised genes (64 protein-coding) were 16 genes (protein-coding by definition) based on NS or UTR variants (Supplementary Table 13). These include SLC39A8 in which rs13107325, previously a moderately high credible SNP23, is now strongly supported as causal (PP > 0.99). Other non-synonymous variants with high PP were found in genes with minimal functional characterization including THAP8, WSCD2, and in two E3 ubiquitin ligases PJA1 and CUL9. Missense and UTR variants prioritised interferon regulatory factor 3 (IRF3 while KLF6, a transcription factor, was highlighted by three variants in the 3’ UTR. Finally, we identified 61 genes (55 protein-coding) in which the 95% credible set is restricted to a single gene (Supplementary Table 14).
