To detect GWAS associations that are credibly explained by eQTLs, that is, variants that influence gene expression, we used summary-based Mendelian randomisation (SMR)24 to find evidence that GWAS signals co-localise with eQTLs (from adult brain25, fetal brain26 or whole blood27) and the HEIDI test24 to then reject co-localisations due to LD between distinct schizophrenia-associated and eQTL variants (Supplementary Table 16). To retain brain relevance, we considered only findings from blood that replicated in brain. After removing duplicates identified in multiple tissues (Supplementary Tables 17a–c), we identified 101 SMR-implicated genes (Supplementary Table 17d); the use of alternative methodologies supported the robustness of the SMR findings (Supplementary Note and Supplementary Table 17e).
