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Chunk #19 — RESULTS — Theoretical Analysis of MTAG’s Performance

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Multi-trait analysis of genome-wide association summary statistics using MTAG.
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This section briefly discusses three analytic formulas we have derived regarding the expected performance of MTAG for each trait: its mean squared error (MSE) across SNPs, its statistical power to detect a true single-SNP association, and its false discovery rate (FDR) (Online Methods). All the formulas hold for an arbitrary number of traits. Supplementary Note contains illustrative calculations.