Chunk #3 — Results — 43 new signals for lung function

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Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.

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signals in the MHC region for both FEV1 (β (s.e.) = 0.048 (0.007), P=5.71×10-13, Supplementary Figure 6a) and FEV1/FVC (β (s.e.) = 0.062 (0.007), P=1.17×10-20, Supplementary Figure 6c) with secondary non-HLA gene signals in the MHC region remaining after conditioning on the HLA-DQβ1 position 57 variant for rs34864796:G>A (near ZKSCAN3, FEV1; conditional β (s.e.) = -0.058 (0.01), P=1.26x10-9, Supplementary Figure 6b) and rs2070600:C>T (in AGER, FEV1/FVC; conditional β (s.e.) = 0.120 (0.013), P=4.23x10-20, Supplementary Figure 6d), (Supplementary Table 6).