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Chunk #4 — Results — 43 new signals for lung function

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Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
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We identified that 29 of the lung function-associated signals had previously shown genome-wide significant association in GWAS of traits other than lung function or COPD. This included associations with inflammatory bowel disease (Crohn’s disease and/or ulcerative colitis, 3 signals) and height (9 signals, 3 of which showed a consistent direction of effect on height and the lung function measure with which they were most strongly associated) (Supplementary Table 7). With the exception of KANSL116, there was no significant (P<5.15x10-4) association with smoking for any of the signals (Supplementary Table 8).