encoded by CHRNA2 is a subunit of certain nicotinic acetylcholine receptors and Demontis et al.11 provide three potential biological explanations for the link between cannabis intake and CHRNA2. However, it is possible that while CHRNA2 is associated with cannabis dependence, it does not play a role in the initial stages of cannabis use, which are more related to personality and risk-taking behaviours and less to the actual effects of cannabis intake on the brain.
