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Chunk #20 — MATERIALS AND METHODS — Zygosity Determination and Genotyping

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Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes?
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yes

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For each chromosome, all genotypes for that chromosome were merged into a data structure after applying the relevant correction rules. Mendelian inheritance checks were then applied automatically, and error genotypes removed across whole families. These data were then further cleaned using MERLIN. Relationship checks on the merged dataset were also performed to check for problems not detectable from individual genome scans.