The participants in this study were drawn from 775 families participating in a long-term longitudinal investigation directed at elucidating the etiology of SUD. Numerous studies conducted on this cohort have explored genetic, biochemical, physiological, psychological, and social contextual influences pertinent to the development of SUD between childhood and adulthood.1 To qualify for participation in this study, the children (254 boys and 85 girls) were required to have had at least one lifetime experience with both alcohol and cannabis subsequent to the baseline assessment conducted when they were 10 to 12 years of age.
