(any, self-reported; Hinds et al. 2013; Pickrell et al. 2016), asthma (self-reported; Pickrell et al. 2016), atopic dermatitis (EArly Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium 2015), childhood ear infection (self-reported; Pickrell et al. 2016), celiac disease (Dubois et al. 2010), serum C-reactive protein (CRP; Dehghan et al. 2011), Crohn’s disease (CD; Franke et al. 2010; Liu et al. 2015), hypothyroidism (self-reported; Pickrell et al. 2016), primary biliary cirrhosis (PBC; Cordell et al. 2015), psoriasis (Tsoi et al. 2015), rheumatoid arthritis (Okada et al. 2014), systemic lupus erythematosus (SLE; Bentham et al. 2015), susceptibility to pulmonary tuberculosis (Curtis et al. 2015), type 1 diabetes (Bradfield et al. 2011), and ulcerative colitis (UC; Anderson et al. 2011; Liu et al. 2015) These phenotypes were treated as a set in subsequent analyses.