With these caveats in mind, our study, which to date is the largest study of resting state connectivity in FHP and FHN participants, found evidence for reduced sensorimotor network connectivity, a finding that was related to the number of family members with alcohol use and mood disorders. At the same time, family history group differences in connectivity were much weaker than the large number of internetwork connectivity differences that were found comparing participants 13 to 14 years of age to those 17 to 18 years of age. Consequently, relatively subtle differences in connectivity in FHP individuals may appear to be independent of age-related changes in the connectome.
