is no substance use history. Indeed, some brain measures may show a more striking difference between FHP and FHN participants prior to adolescence.43 Our resting state scan, albeit at least as long as other resting state studies in FHP individuals,16,17 could have benefited from longer duration.44 Finally, because we used a data-driven ICA approach to examine connectivity across the entire set of brain voxels, we did not focus on specific brain regions. In addition, unlike region of interest based approaches, it is not possible to “scrub” individual time points of high motion data, as these analyses require all participants to have an equal number of time points of fMRI data.
