Table 1 shows the results of the association in all six samples for rs1545843 as well as two SNP in moderate LD with it, rs1031681 and rs7975057. Testing the recessive model of rs1545843, we observed nominally significant association in four of the five replication samples, with the same direction of the effect in all samples. A meta-analysis conducted across all samples resulted in a genome-wide significant association with a p-value of 2.34e-08 (4.37e-08 corrected for three tested genetic models) for the recessive model of rs1545843 (see tab. 1). Homozygote carriers of the A-allele of this SNP had a 1.42-fold higher risk to suffer from depression and depressive symptoms compared to carriers of the two other genotypes.
