who reported more than 99 lifetime sexual partners were asked to confirm their responses. We assigned a value of zero to participants who reported having never had sex, and we again normalized this measure separately for males and females. Our first PC phenotype is the first PC obtained from a principal component analysis (PCA) in the UKB of the four risky behaviors (Supplementary Table 23). All seven phenotypes were coded such that higher phenotype values are associated with higher risk tolerance or risk taking. Table 1 lists, for each GWAS, the datasets we analyzed and the GWAS sample size. The Supplementary Note and Supplementary Tables 4 and 5 provide additional details on the cohorts and phenotype definitions.
