Chunk #6 — Materials and methods — Drugs

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The α2-adrenergic receptor agonist, clonidine, reduces alcohol drinking in alcohol-preferring (P) rats.

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Clonidine hydrochloride (Sigma-Aldrich Co., St. Louis, MO) was dissolved in 0.9% NaCl. In Study 1, each rat received an IP injection of saline vehicle or 10, 20, 40, or 80 µg clonidine/mL saline/kg BW. In Study 2, each rat received an IP injection of saline vehicle or 40 µg clonidine/mL saline/kg BW.