Chunk #29 — Results — Associations of CD with the positive variants identified in the EA family sample in the other three independent samples

Source

Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.

Embedded

yes

Text

In subjects carrying the SNP3^G allele, the frequency of SNP8^T/T in CD cases was significantly higher than controls (P=0.008, OR=1.8, 95%CI: 1.1~ 2.9), while no significant difference was observed within subjects not carrying SNP3^G. On the other hand, in CD subjects carrying SNP8^T/T, the frequency of SNP3^G+ was nominally higher than in controls (P=0.024, OR=1.6, 95%CI: 1.0~2.4), but no difference was observed within subjects not carrying SNP8^T/T (P>0.05) (Table 4, Figure 4).