Chunk #30 — Results — Associations of CD with the positive variants identified in the EA family sample in the other three independent samples

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Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.

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In the AA family sample, we observed that SNP8^T/T significantly increased risk for CD (P=0.019) while adjusting for sex and age. However, neither SNP3 nor the interaction between SNP3^G+ and SNP8^T/T was significantly associated with CD (P>0.05). In the haplotypewise analysis, no association between CD and SNP8-containing haplotypes was observed.