Chunk #31 — Results — Associations of CD with the positive variants identified in the EA family sample in the other three independent samples

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Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.

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In the AA case-control sample, as shown in Table 3, the allele frequency distributions for both SNP3 and SNP8, and the genotype frequency distribution for SNP8 in cases, were not significantly different from controls. The genotype frequency distribution for SNP3 in cases was significantly different from controls, however the difference did not reach statistical significance while adjusted for sex and age, and corrected for multiple testing (P=0.028, α=0.025). We failed to observe an interaction between SNP3 and SNP8 having a significant effect on CD in the AA case-control sample.