Our study provides further support for the association of schizophrenia with common variant alleles and haplotypes in ZNF804A. We replicate the previously reported observation of genetic association between schizophrenia and the A allele of rs1344706. In an extended set of tSNPs, we also observe association with the minor T allele of rs7597593, with a haplotype containing the A allele of rs1344706, and with a haplotype containing the A allele of rs1344706 and the T allele of rs7597593. Only the single marker results from rs7597593 remain significant after Bonferroni correction, and only the results from the longer haplotype including rs7597593 remain significant after permutation testing. LD and haplotypes agree closely with prior observations in other European-descended samples. There is no evidence for differential association with ZNF804A between male and female cases or between cases with and without a positive family history of schizophrenia-like illness.
