Rs910083-C, the minor allele for EUR (frequency=44%) but the major allele for AA (frequency=77%), is associated with increased nicotine dependence risk (Table 1): EUR-specific meta-analysis P=4.1×10−5 and OR (95% CI)=1.06 (1.03–1.08); and AA-specific meta-analysis P=7.3×10−5 and OR (95% CI)=1.10 (1.05–1.15). Many SNPs/indels were in moderate to high LD (r2>0.4) with rs910083 in 1000G EUR, spanning 220 kb (chr20:31,268,924–31,488,466) and including DNMT3B and its neighboring genes, microtubule-associated protein, RP/EB family, member 1 (MAPRE1) and COMM domain containing 7 (COMMD7). However, in 1000G AFR, SNPs in LD (r2>0.4) with rs910083 were localized to a 47 kb region (chr20:31,356,560–31,403,394) including only DNMT3B (Figure 2A–B, NCBI build 37 positions).
