Rs910083, an intronic DNMT3B SNP, was identified across both ancestries: meta-analysis P=3.7×10−8 and β (standard error)=0.032 (0.0057) for the C allele (Table 1), corresponding to OR (95% confidence interval [CI]) of 1.06 (1.04–1.07) for severe vs mild dependence (Supplementary Figure 3). Rs910083 was imputed well (quality scores=0.98–1), and it showed no evidence of heterogeneity across studies (P=0.71).
