Chunk #17 — Materials and Methods — Effects of systemic AM3506 treatment — Pre-reactivation treatment

Source

Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity.

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Here, the extinction session was replaced with a 3 × CS session. AM3506 was administered at a dose of 0 or 1.0 mg/kg 60 min before reactivation. The purpose was to test whether AM3506 reduced long-term fear by impairing reconsolidation of the fear memory, rather than by facilitating extinction.