Growth factor receptor-bound protein 2-associated-binding protein 2 (GAB2) molecules are intracellular docking or scaffolding molecules. GAB2 can be involved in several signal transduction processes, associated with cell growth, survival, differentiation, and apoptosis. GAB2 might play a role in the suppression of Tau phosphorylation and in neurofibrillary tangles (NFTs) formation. Reiman et al detected six SNPs in GAB2 (chromosome 11) which might be associated with LOAD.166 Interaction was found between GAB2 haplotypes and the APOE E4 allele.166–168
