The cadherin-associated protein alpha 3 (CTNNA3) gene located on chromosome 10 encodes alpha-T catenin, which can be involved in AD pathogenesis by binding to beta-catenin and interacting with PS1. Miyashita et al identified seven putative LOAD risk-factor polymorphisms located at intron 9 of CTNNA.164 Polymorphisms in CTNNA3 have shown significant association with LOAD in female patients, who carried the APOE E3 allele, but not the E4.164,165
