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Chunk #28 — Results — Examination of variants distinguishing BP and SCZ

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Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
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To investigate further, we took all 22 genome-wide significant loci from a recently submitted SCZ analysis (Ripke et al.) and compared the odds ratios between our independent BP and SCZ datasets. The data are ordered left to right by significance for BP (Figure 3). There is a spectrum of BP effects for statistically significant SCZ loci with loci on the left displaying odds ratios similar in magnitude between the two diseases, while loci on the right, having divergent odds ratios.