sample was disproportionately contributing to the result. Risk scores were calculated for p-value thresholds from 0.001 to 1 as defined in (12). All samples had at least one threshold reaching nominal significance with all but one sample explaining at least 2% of the variance (Figure 2, Supplementary Table 4a-b). These results suggest that we have successfully identified a polygenic signal capable of detecting risk differences between BP and SCZ.
