Chunk #147 — IV. Results of tests of clustering within individual samples and tests of convergence between replicate samples for the same phenotypes — F. Cognitive ability (Samples 15 and 16)
Of the 489,922 autosomal SNPs assessed in Sample 15, 46,361 displayed correlations with cognitive ability assessments with nominal p < 0.05 (Uhl et al, submitted). 19,781 of these nominally-significant SNPs fell into 4,016 clusters in which at least three nominally-positive SNPs sampled on two array types lay within 25 kb of the neighboring nominally-positive SNP. Similarly, of the 489,922 autosomal SNPs that were assessed in Sample 16, 36,689 displayed correlations with cognitive ability with nominal p < 0.05. 11,376 of these nominally-significant SNPs fell into 2,556 clusters. None of 100,000 Monte Carlo simulation trials that sampled at random from the same databases found this degree of clustering of nominally-positive SNPs by chance for either sample (p < 0.00001).
