Chunk #146 — IV. Results of tests of clustering within individual samples and tests of convergence between replicate samples for the same phenotypes — E. Success in smoking cessation (Samples 12, 13, 14)

Source

Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

Embedded

yes

Text

Convergent data from at least two of the three quit success comparisons: Nominally-positive clustered SNPs from successful vs unsuccessful quitter comparisons from Samples 12 – 14 also cluster together on small chromosomal regions to extents much greater than chance [36]. The Monte Carlo p values for the replication for samples 12 vs 13, 12 vs 14 and 13 vs 14 are 0.00054, 0.0016 and 0.00063, respectively.