To investigate genetic overlap at the genome-wide level, we estimated genetic correlations with self-reported general risk tolerance using bivariate LD Score regression9. (For this and all subsequent analyses involving general risk tolerance, we used the summary statistics from the combined meta-analysis of our discovery and replication GWAS.) The estimated genetic correlations with our six supplementary phenotypes are all positive, larger than ~0.25, and highly significant (P < 2.3×10–30; Fig. 2), indicating that SNPs associated with higher general risk tolerance also tend to be associated with riskier behavior. The largest estimated genetic correlations are with adventurousness (r^g = 0.83, SE = 0.01), number of sexual partners (0.52, SE = 0.02), automobile speeding propensity (0.45, SE = 0.02), and the first PC of the four risky behaviors (0.50, SE = 0.02).
