Another long-range LD region, on chromosome 6 (~25.3 to 33.4 Mb), covers the HLA-complex and contains lead SNPs from all GWAS except drinks per week. Three candidate inversions on chromosomes 7 (~124.6 to 132.7 Mb), 8 (~7.89 to 11.8 Mb), and 18 (~49.1 to 55.5 Mb) contain lead SNPs from six, five, and all seven of our GWAS, respectively. Finally, four other LD blocks19 that do not overlap known long-range LD or candidate inversion regions each contain lead SNPs from five of our GWAS (including general risk tolerance). While many of the lead SNPs in these regions are not conditional associations, the above results regarding the numbers of GWAS with lead SNPs in these regions also hold if we only consider the conditional associations instead of the lead SNPs in those regions. The two long-range LD regions and the three candidate inversions have previously been found to be associated with numerous phenotypes, including many cognitive and neuropsychiatric phenotypes20.
