Chunk #36 — Results — 5. Haplotype effects on Subjective Responses to Alcohol — 5. A. Block 1: intergenic region 5′ GABRG1-3′ GABRA2 and GABRA2 region — 5. A.1. Visual Analog Drug Effect Questionnaire (VAS)
Carriers of one or two copies of block 1, haplotype 1, GTGGTACCTCTTAGCAGC, had significantly lower mean alcohol “Negative” effects scores (14.18, SE = 3.93) than non-carriers [mean = 23.17 (SE = 3.26), (F(1, 49) = 4.07, p=0.0492)] (Figure 5). Similarly, carriers of one or two copies of block 1, haplotype 4, ACGATGTTGTTATAATAT, had significantly lower mean alcohol “Negative” effects scores (17.19, SE = 3.84) than non-carriers [mean = 20.86 (SE = 3.30)], after adjusting for time, BAC, and number of binge drinking episodes (F(1, 49) = 6.36, p=0.0150) (Table 5).
