Chunk #37 — Results — 5. Haplotype effects on Subjective Responses to Alcohol — 5. A. Block 1: intergenic region 5′ GABRG1-3′ GABRA2 and GABRA2 region — 5. A.2. Biphasic Alcohol Effects Scale (BAES)

Source: GABRA2 markers moderate the subjective effects of alcohol.
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Carriers of one or two copies of block 1, haplotype 3, ACTATGTTGTTATAATAT, had significantly higher mean alcohol sedative effects scores (5.32, SE = 0.43) than non-carriers [mean = 2.69 (SE = 0.34), after adjusting for time, BAC, and age (F(1, 49) = 4.94, p=0.0309)]. In contrast, carriers of one or two copies of block 1, haplotype 4, ACGATGTTGTTATAATAT, had significantly lower mean alcohol sedative effects scores (2.76, SE = 0.40) than non-carriers [mean = 4.84 (SE = 0.36)], after adjusting for time, BAC, and age (F(1, 49) = 7.62, p=0.0081) (Table 5).