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Chunk #21 — RESULTS

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Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression.
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Table 1 lists results from analyses across all age groups based on exposure to our two stressors of interest and diagnoses of our two depression outcomes. As expected, our two positive control factors, sex (OR < 1, indicating that males are at lower risk) and exposure to stress (OR > 1 indicating that exposure to stress increases risk), each have strong, consistent, and highly statistically significant associations to diagnoses of depression whether the diagnosis was for lifetime depression or current depression at the time of assessment. We do not see a main effect association between number of copies of the S allele and depression in these analyses, a finding that matches what we would expect from prior reports, including the study originally reporting the interaction.16