This current report focuses only on the 1,684 non-Hispanic participants who received the first 12 weeks of medication. Study participants were randomized to receive one of three treatment assignments for 12 weeks: 300 mg of bupropion SR per day (150 mg bid), ad libitum use of a nicotine inhaler (up to 16 cartridges per day), or a combination of both the nicotine inhaler and bupropion. The primary endpoint for the study was the smoking status at the end of the treatment period.