Potential subjects were eligible for enrollment if they were at least 18 years of age, had smoked at least ten cigarettes/day for at least 12 months, were motivated to use the study medication according to the study protocol, were in general good health, had the ability to participate in all aspects of the study, and provided written informed consent. Potential subjects were excluded if they were pregnant/breast-feeding, using concurrent behavioral/pharmacologic treatments to stop smoking, using tobacco products other than cigarettes, or taking an investigational drug. Subjects were also excluded if they had a known hypersensitivity/allergy to nicotine, bupropion, or menthol, unstable angina/myocardial infarction, a history of bulimia/anorexia nervosa, seizure disorders, serious head trauma or other predisposing factors to seizure, or chemical dependence on any drug other than nicotine in the past year. Subjects were also excluded if they were using antipsychotics, antidepressants, theophylline, systemic steroids, antiepileptic medications, or a monoamine oxidase inhibitor (MAO-I).
