This study includes data from the dorsolateral prefrontal cortex provided by the MSSM, Penn, and Pitt brain banks. Tissue for the study was dissected at each brain bank and shipped to the Icahn School of Medicine at Mount Sinai (ISMMS) for nucleotide isolation and data generation in one facility in order to reduce site-specific sources of technical variation. Postmortem tissue from schizophrenia and bipolar disorder cases were included if they met the diagnostic criteria in DSM-IV for schizophrenia or schizoaffective disorder, or for bipolar disorder, as determined in consensus conferences after review of medical records, direct clinical assessments, and interviews of care providers. Cases that had a history of Alzheimer’s disease, and/or Parkinson’s disease, or acute neurological insults (anoxia, strokes, and/or traumatic brain injury) immediately prior to death, or were on ventilators near the time of death, were excluded. Eight samples were classified as a mood disorder other than bipolar post sample collection and have been labeled as AFF in the clinical file.
